Enabling Electrochemistry and Photochemistry: Transitioning from g to kg scale

Abstract: Electrochemistry and photochemistry can enable new and different bond disconnections, with the potential to streamline synthesis and provide access to new regions of chemical space. Moreover, both electrosynthesis and photochemistry offer greener alternatives to traditional approaches by avoiding the use of stoichiometric and potentially hazardous redox reagents, thereby advancing sustainable chemistry goals. However, realizing the full potential of these activation modes in the pharmaceutical industry requires not only the development of new synthetic methods but also the design of suitable reactor technologies and workflows. This presentation will highlight our efforts in implementing electrochemical and photochemical transformations in process chemistry, focusing on the development of an ideal workflow for reaction scale-up in continuous flow. Case studies for both electrochemical and photochemical reactions will be used to illustrate the scaling strategy and the reactors employed, including the transition from lab-scale results to kilogram-scale demonstrations.