Advancing sustainability in peptide, oligonucleotide, and bioconjugate production: An overview of the ACS GCIPR focus teams

Abstract: The use of peptides, oligonucleotides, and bioconjugates as therapeutics has experienced rapid and transformative growth in recent years, delivering substantial benefits to patient health and well-being. However, the production of these types of therapeutics has historically utilized processes that involve the extensive use of hazardous reagents, large volumes of solvents, and high process mass intensities. The ACS Green Chemistry Institute Pharmaceutical Roundtable is a forum where global pharmaceutical and allied industries collaborate to advance the sustainability of manufacturing medicines by implementing green chemistry & engineering. An overview of the sustainability initiatives and work advanced by three of the ACS GCIPR Focus teams – Peptides, Oligonucleotides, and Bioconjugates – will be highlighted.