Engineering enzymes for green manufacturing of noncanonical amino acids

Abstract: Aralez Bio uses biocatalysis to unlock the synthesis of noncanonical amino acids. Using directed evolution, we develop enzymes to synthesize new amino acids needed for innovations in pharmaceuticals, food, agriculture, and functional materials. Our proprietary enzymes catalyze an array of bond-forming and transformation reactions with a broad range of readily available substrates, enabling us to manufacture over a thousand enantiopure noncanonical amino acids from mg to 100 kg scale. Through increased efficiency and product scope, Aralez Bio supports the development and manufacture of new peptides more quickly and cleanly than ever before.