iGAL 3.0: Advancing standardized green chemistry metrics in Pharma(Note: Title subject to change pending acceptance of the iGAL 3.0 paper prior to the GC&E conference)

Abstract: The innovation Green Aspiration Level (iGAL) metric has become a foundational industry benchmark for assessing the environmental performance of API manufacturing. While iGAL 2.0 successfully standardized waste based greenness evaluation, its reliance on molecular size (FMW) limited its ability to account for structural complexity. iGAL 3.0 addresses this gap by integrating machine learning-derived molecular features to generate more accurate, complexity adjusted waste targets. This enhanced model delivers improved predictive performance, higher R-sq values, and more realistic greenness benchmarks across diverse APIs. In addition, a new open access web-based Scorecard tool allows users to input API structures, process waste (cEF), and development phase to rapidly benchmark Relative Process Greenness (RPG). Together, iGAL 3.0 and its digital implementation provide a more nuanced assessment framework, supporting alignment with global sustainability goals and advancing standardized green chemistry metrics across the Pharmaceutical industry.