Safer synthetic conditions and substances The ACS GCI pharmaceutical roadmap for sustainable API manufacturing

Abstract: Many substances used across the supply chain to produce APIs are harmful to human health and the environment. Substances used in API manufacturing may be directly hazardous to humans and the environment or may cause indirect hazards stemming from their production. And API molecules themselves may cause harm when they are excreted to the environment after use. At the same time, many chemistries used across the API supply chain present safety risks to plant operators and nearby communities. In this presentation we will discuss the need to develop safer alternatives to the most hazardous substances and chemistries used in API production. And where use of hazardous substances is unavoidable, new technologies and practices are needed to improve the safety of handling these substances and to prevent their release to the environment after their intended use.