Enabling net-zero API manufacturing by 2045: A tools-focused roadmap for the ACS GCIPR

Abstract: Achieving net zero API manufacturing by 2045 will require a new generation of practical, science-based tools that empower rapid, data-driven sustainability decisions across the pharmaceutical value chain. As part of the ACS GCIPR API Strategy Roadmap, we identified the critical tool gaps limiting wider adoption of green chemistry - including the need for integrated metrics platforms (PMI-LCA and iGAL), predictive eco-design and feedstock selection tools, improved digital decision support frameworks, and harmonized data standards. This presentation outlines the priority tools needed to evaluate, benchmark, and optimize greener API synthetic routes, and enable circularity. The resulting roadmap defines a practical, industry-aligned pathway for equipping chemists and engineers with the capabilities required to design and manufacture more sustainable APIs at scale.