11: Optimization and utilization of a ferrocene-templated approach to prepare variants of Chalaniline a for exploration of its biological mode of action and structure activity relationships

Abstract: Chalaniline A is a structurally unique aminofulveno[1,2-b]chromone derivative that was isolated from a vorinostat-treated ascomycete culture (Chalara sp. 6661) by Loesgen et al. in 2017. Recent studies of the biological activity of chalaniline A have revealed a range of significant properties, among them inhibition of nociception (analgesia), that warrant further investigation of this compound and related substances. In beginning to address this aim, ongoing work to adapt our recently disclosed ferrocene-templated total synthesis of chalaniline A to secure a variety of new structural analogues for SAR and biological mode-of-action studies, will be presented.